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A NEW ADVANCMENT IN DIAGNOSING PJI
The Lyfstone® Calprotectin test for synovial fluid is an accurate diagnostic aid that identifies the risk of infection within 15 minutes.

LYFSTONE® CALPROTECTIN

A new advancement in diagnosing PJI

The Lyfstone® Calprotectin test for synovial fluid is an accurate diagnostic aid that identifies the risk of infection within 15 minutes.

A new advanced, diagnostic aid that helps orthopaedic surgeons identify the risk of periprosthetic joint infection (PJI). The Lyfstone Calprotectin test is easy to use and delivers reliable results in just 15 minutes.

Fast and easy – to assess the risk of periprosthetic joint infection, a small amount of synovial fluid is subtracted from the patient’s joint.  This test requires only 20ul and generates results in 15 minutes.  The easy sample work-up allows implementation at any stage of care, from consulting to pre-op to per-op.

Clear and reliable risk indicators – the test allows for clear and reliable categorisation of patients based on the level of calprotectin found in the synovial fluid.

An infected prosthetic joint should be operated on urgently, so ruling out infection is a top priority. The presence of neutrophils is a characteristic of prosthetic joint infection, and infections cause a large release of calprotectin. The Lyfstone orthopedic test is a CE-IVD labeled bedside test that measures the amount of calprotectin in the patient’s synovial fluid. Calprotectin levels have been shown to be elevated in both acute and chronic prosthetic joint infections.

 

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    • The synovial fluid calprotectin lateral flow test for the diagnosis of chronic prosthetic joint infection in failed primary and revision total hip and knee arthroplasty. Suren, Prodinger, et al. 2023

 

    • Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Periprosthetic Joint Infection After Total Knee Arthroplasty: A Prospective Cohort Study. Warren, Higuera, et al. 2021

 

 

    • Synovial Calprotectin for Diagnosing Periprosthetic Joint Infection in Loose Hip and Knee Arthroplasties: A Prospective Cohort Study. Lazic, Suren, et al. 2023

 

 

    • Utility of synovial calprotectin lateral flow test to exclude chronic prosthetic joint infection in periprosthetic fractures: a prospective cohort study. Lazic, Suren, et al. 2022

 

 

 

    • Evaluation of an upgraded synovial calprotectin lateral flow assay in unclear cases of hip and knee prosthetic joint infections. Hartmann, Hofstaetter et all 2023

 

 

Upcoming:

  • Economic study, Amphia Utrecht and Erasmus Rotterdam, 100 patients, expected 2024
  • THE DIAGNOSTIC ACCURACY OF INTRAOPERATIVE SYNOVIAL FLUID CALPROTECTIN IN SUSPECTED LOW-GRADE PERIPROSTHETIC HIP JOINT INFECTIONS, Macheras et all, Greece, 48 patients, expected 2024
  • Validation study, Tsiridis Greece, 30 patients, expected 2024
  • The Diagnostic Value of Calprotectin Point of Care Testing in the Second Stage of a Two-Stage Procedure for the Treatment of Periprosthetic Hip and Knee Joint Infections, Hartmann and Hofstaetter, 145 patients, expected April 2024
  • Re-revison cases, dr Lazic Munich Germany, 50 patients, expected 2024
  • Validation study, Madrid-Valencia Spain, 230 patients, expected 2025
  • Validation study, Martina Hansen Norway, 100 patients, expected 2024

 

DOCUMENTS TO DOWNLOAD

HOW TO DO THE TEST