The Lyfstone® Calprotectin test for synovial fluid is an accurate diagnostic aid that identifies the risk of infection within 15 minutes.

joint

In a prosthetic joint, the first priority is to reliably rule out infection. The Lyfstone® test is a CE-IVD labelled Point of Care test, which measures the amount of Calprotectin in Synovial Fluid. Calprotectin is abundantly present in neutrophils. The presence of neutrophils is a hallmark of PJI, and a massive release of calprotectin occurs upon encounter with pathogens. Elevated levels of calprotectin are proven indicators of both acute and chronic PJI.

A new advancement in diagnosing PJI

Precise results

The lateral flow rapid test is combined with the Lyfstone® app to give an exact quantitative measurement of the level of calprotectin in Synovial fluid. Just hold the smartphone above the sample and align the screen layout with the support frame. The calprotectin concentration and the risk stratification group of the sample are displayed on the screen.

To assess the risk of periprosthetic joint infection, a small amount of synovial fluid is extracted from the patient’s joint. The Lyfstone® test requires only 20 μl and generates results in 15 minutes. The easy sample work-up allows implementation at any stage of care, from consulting to pre-op to per-op.

you asked we answer

Calprotectin is a small protein, normally comprised of two subunits.  The protein is produced in abundant amounts in neutrophil cells, normally about 45% of the total cytosolic protein in the cells. The protein is also produced in many other types of cells. Calprotectin plays several roles in the human immune system. Perhaps the most important role is as an early signal when a pathogen is being detected and targeted, activating innate immune cells and allowing the orchestration of an inflammatory response. 

In relation to Lyfstone® ’s use of Calprotectin as a biomarker, this happens when neutrophil cells swarm into an infected joint. The cells activate and burst, releasing large amounts of pre-produced Calprotectin into the synovial fluid. This means that the signal the Lyfstone® test detects is clear and strong, and well-connected to the clinical issue at hand.

General information about Calprotectin based on the field of medicine where the protein has been used the most:

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